Description
Retatrutide (LY3437943) is an investigational once-weekly injectable peptide that acts as a triple agonist, targeting GIP, GLP-1, and glucagon receptors. It induces significant weight loss—up to 24% over 48 weeks in trials—by reducing appetite, slowing digestion, and increasing metabolism.
Key Information on Retatrutide
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- Mechanism of Action: Known as a triple-agonist, it mimics three natural hormones (GIP, GLP-1, and Glucagon) to improve glycemic control and maximize metabolic effects (energy expenditure and fat reduction).
- Effectiveness: Phase 2 studies showed that 48 weeks of treatment led to an average weight loss of 24.4%
. It is considered a potential next-generation weight loss therapy.
- Administration: It is designed to be a once-weekly subcutaneous injection.
- Common Side Effects: Consistent with the GLP-1 class, side effects are primarily gastrointestinal, including nausea, vomiting, and diarrhea.
Differences from Current Medications
While popular, current drugs (semaglutide) and (tirzepatide) target one or two receptors, respectively, whereas retatrutide’s addition of the glucagon receptor agonism is aimed at increasing energy expenditure.
Warnings and Side Effects
- Contraindications: Individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use it.
Other Risks: Potential for hypoglycemia, particularly if used with other diabetes medications.
Patients reach and maintain lower HbA1c and weight levels.
Disclaimer: This information is for educational purposes based on research studies and does not constitute medical advice. Consult a healthcare provider before starting any peptide therapy.
Ana Algarin –
I tried for 5 years to get past 165 lbs.
Carnivore diet ✅
Consistent movement ✅
Water, sleep, mindset work ✅
And I was STUCK. For years.
In August 2025, I added Retatrutide to my routine. Three months later, I hit 145 lbs — my goal weight that I’d been chasing since 2020. I stopped taking it at the end of October. And kept losing.
Today I’m 138 lbs. Heading toward my original dream of 135.
I believe the combination of the Wolverine Stack healing my gut and my body — paired with carnivore — created the foundation. Retatrutide was the key that finally unlocked the door.
I’m not promising miracles. I’m sharing my truth. And my truth is 55 lbs gone and a life I genuinely love living.